This insightful text looks at key risk factors identified with drug use among Hispanic, African-American, and White non-Hispanic adolescents, expanding on current models of drug research to account for the unique experiences of these young people. The model underlying the research draws components from three theoretical models: self-derogation/self-esteem; acculturation stress; and perceptions of racial and cultural prejudice and discrimination. By integrating these theories, the authors generate hypotheses and general research questions within the context of adolescents' ethnic and social environments. The eight chapters underscore the importance of the culture, neighborhoods, and social strata in understanding life course drug use and behavior.