Originally published: 2018.

Introduction. Designer Drugs: Legislating for Tomorrow Through the Use of Class Definitions and Pharmacophore Principles. Alternative Legislation with Designer Drugs. Biological Precursors of Designer Drugs. Liquid Chromatography - Mass Spectrometry in Analysis of Designer Drugs. Ambient Plasma Ionization Techniques in Forensic Analysis. Application of LC-QTOFMS for the Identification of the Structure of New Psychoactive Substances. Rapid Generation of Metabolites by Electrochemical Method. Gas Chromatography - Mass Spectrometry in Analysis of Designer Drugs. NMR Spectroscopy in the Analysis of Designer Drugs. Preparation of Biological Material for Toxicological Analysis. Discrimination among the Designer Drug Isomers by Chromatographic and Spectrometric Methods. Liquid Chromatography-Mass Spectrometry and Ambient Mass Spectrometry Applied to the Analysis of Synthetic Cannabinoids. Cathinone Derivatives and Their Analysis. NBOMe Derivatives of Phenylethylamines and Their Analysis. 2C Derivatives of Phenylethylamines and Their Analysis. Modern Techniques for the Analysis of Piperazines. Fenantyl Analogues and Their Analysis. Modern Techniques for the Identification of Tryptamines. Toxicological Analysis of New Opioids. Toxicological Analysis of Designer Benzodiazepines. Thin-layer Chromatography in the Analysis of Designer Drugs

This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.